Research

Research

Diabrisk-sl : Evaluation of risk factors in the development of Type 2 diabetes and cardiovascular disease and correction through non pharmocological Life Style Modification in Young Urban Sri Lankan Population

The study objective was aimed at reducing the burden of T2DM with a low cost primary prevention strategy.

It was a randomised control parallel group clinical trial based on cluster sampling. 23,296 (5-40 yrs) healthy young urban subjects (males 47%) were screened for 4 risk factors (RFs): increased BMI, increased waist circumference (WC), Physical inactivity (PA), and family history (FH). 23% of participants had ≥2Risk factors (n = 5164) while 4682 volunteered to be followed up for 4 years with advice on Intensive-Life style modification [Study ] (3 monthly n= 2352) and Less Intensive –Life style modification [Control ] (12 monthly n= 2330) on a one to one basis.

Results: Baseline

  • 23% had 2 or more risk factors
  • Physical Inactivity 39%;>WC 31.7%; first degree family history 26.2%;>BMI 20.9%
  • Dysglycaemia <20yrs – 8.2%, [DM + pre-DM] >20yr – 22.1% and Overall- 15.3%

Final results:

  • RELATIVE RISK REDUCTION [RRR] in new onset of type 2 Diabetes 26%
  • RRR of IGT 18%
  • Primary endpoints 9%
  • Regression from prediabetes to normoglycaemia 50%

Diabrisk-sl is a study carried out by the DASL in collaboration with the Metabolic Unit of  Kings College London –UK.

This project was supported by a BRIDGES Grant from the International Diabetes Federation. BRIDGES, an International Diabetes Federation project, was supported by an educational grant from Lilly Diabetes and a grant awarded from the Diabetes Association of Sri Lanka.

Publications

  • Wijesuriya et al., 2019. Characteristics of Insulin Registry Patients with Type 1 Diabetes in Sri Lanka. Journal of Diabetology. | Volume: 10 | Issue Number: 1 | Page: 37-40 – Read More
  • Wijesuriya et al., 2017, A pragmatic lifestyle modification programme reduces the incidence of predictors of cardio-metabolic disease and dysglycemia in a young healthy urban South Asian population: a randomized controlled trial, BMC Medicine 15:146. – Read More
  • Wijesuriya et al., 2014. A low cost primary prevention tool: effects of non pharmacological lifestyle modification in prevention of type 2 diabetes mellitus in young urban Sri Lankan – “DIABRISK-SL”. Diabetes Research and Clinical Practice. Vol 106, Supplement 1: S25-S26. – Read More
  • Wijesuriya, et al.,2012. High Prevalence of Cardio-Metabolic Risk Factors in a Young Urban SriLankan Population. PLoS ONE 7(2): e31309. – Read More
  • Wijesuriya et al., 2012. Association of chronic complications of type 2 diabetes with the biochemical and physical estimations in subjectsattending single visit screening for complications. Journal of Diabetology, 3(1). – Read More
  • Wijesuriya et al., 2011. DIABRISK – SL Prevention of cardio-metabolic disease with life style modification in young urban Sri Lankan’s – study protocol for a randomized controlled trial. Trials, 12:209 – Read More
  • Guess et al., 2016. Improvements in stage of change correlate to changes in dietary intake and clinical outcomes in a 5-year lifestyle intervention in young high-risk Sri Lankans. Preventive Medicine 90, 193–200. – Read More
  • Guess et al., 2016. The effect of dietary changes on distinct components of the metabolic syndrome in a young Sri Lankan population at high risk of CVD. British Journal of Nutrition, 116, 719–727. – Read More
  • Karalliedde et al., 2014. Effect of lifestyle modification on the prevention of type 2 diabetes and impaired glucose tolerance in a young healthy urban South Asian population. Diabetologia 57.

National and International research collaboration

  • De Zoysa et al., 2018. Eccentricity based Quantification of Retinal Vascular Tortuosity For Early Detection of Diabetes and Diabetic Retinopathy, in: IEEE Systems Man and Cybernetics Conference. Miyasaki,
  • Iroshan, et al., 2018 Detection of Diabetes by the Macro-Vascular Tortuosity of Superior Bulbar Conjunctiva, in: IEEE Engineering in Medicine and Biology Conference. Honolulu, 2018 July.
  • Kesavadev et al., 2014. Challenges in Type 1 diabetes management in South East Asia: Descriptive situational assessment. Indian Journal of Endocrinology and Metabolism, 18(5): 600-607. – Read More
  • Balasuriya et al., 2012. Prevalence of micro and macrovascular complications of diabetes detected at single visit screening in Sri Lanka Journal of Diabetes, Endocrinology and Metabolism, 2: 17-20. – Read More
  • Ranawaka et al., 2010. Clinical profile of type 2 diabetes mellitus in relation to the body mass index. Ceylon Journal of Medical Science 53:23-35.
  • Wijesuriya et al., 2009. The Kathmandu Declaration: “Life Circle” approach to prevention and care of diabetes mellitus. Diabetes research and clinical practice 87(1):20-6. 0 – Read More
  • Katulanda et al., 2008. Prevalence and projections of diabetes and pre-diabetes in adults in Sri Lanka–Sri Lanka Diabetes, Cardiovascular Study (SLDCS).Diabetic Medicine. Sep;25(9):1062-9. – Read More
  • Misra et al., 2007. The metabolic syndrome in South Asians: Continuing escalation & possible solutions. The Indian Journal of Medical Research 125(3):345-54. – Read More
  • Katulanda et al., 2007. High prevalence of diabetes and prediabetic states among urban adults in Sri Lanka. Sri Lanka diabetes and cardiovascular study. Diabetic Medicine 24:27-27
  • Premarathna et al., 2006. Islet cell, thyroid, adrenal and celiac disease related auto antibodies in patients with Type1diabetes from Sri Lanka. J Endocrinol. Invest 29:968-974. – Read More

Journal publications

Diabetes Voice- International Diabetes Federation

  • SaveaLifeCovid-19SL: tackling lockdown to provide essential diabetes supplies in Sri Lanka, Diabetes voice 2020 – Read More
  • Halting rise of diabetes means ensuring health of the girl child: Diabetes Voice 2019 – Read More
  • Mahen Wijesuriya, Chamari Warnapura. Diabetes Voice. Sri Lanka: achieving so much with so little. – Read More